Antiviral Activity of Interferon Alpha-2b and Taurine Combination Against SARS-CoV-2 in vitro

Interferons (IFN) have antiviral activity against many viruses, including SARS-CoV-2. A combination of IFN-a2b and the antioxidant taurine is widely used in Russian Federation, its has not been studied before. The aim this study was to determine interferon drugs, with without it. included cytotoxicity assays preparations, when stored according instructions at 2–8°C, after 1 month storage temperature 20–26°C a pre-opened state. IFN alpha-2b higher compared mono-preparation by more than 25% «low» 85% «high» multiplicity infection. Selectivity index for combinations (50,000 IU/dose) + (1 mg/ml) (10,000 IU/ml) (0.8 600 units, whereas it 200 units. Antiviral does change one room temperature. high concentrations less toxic interferon. results obtained demonstrate practicability use treatment prevention COVID-19.